The chosen day is Wednesday, November 17, and so far the support for the unusual celebration has included Star Trek's William Shatner and Friend's star, Lisa Kudrow.
The concept behind the fake holiday is for surfers with Facebook to spend time weeding out their 'friends', eliminating those who really don't matter to them, people who are not truly their friends.
Shatner told Kimmel, "These people on Facebook, they're not your friends. You want to know who your friends are? Post a status update that says 'I'm moving this weekend and I need help.' The people that respond? Those are your friends! Everyone else isn't."
Actress Lisa Kudrow also gave her support by dropping by the show and delivering a straightforward lecture on the meaning of real friendship.
With all of the recent attention given to hacking and identity theft, cleaning out the Facebook friends section might not be a bad idea. Of course, not everyone is on board, especially those who love the status of having more friends than anyone else.
So, the question is, what does friendship really mean to the individual? National Unfriend Day might just tell the story on that one.