The Simpsons is the original cartoon family on television that can make me laugh like it does. There will be no other show released while I am alive that will top what this family has done for me. American Dad is funny, don't get me wrong. I just don't think it is better than The Simpsons.
Some humorous points in the show do have an edge over the Simpsons, but nothing is going to beat the Simpsons in total. Every show will have something about it that makes it funny, but the Simpsons has everything.